A gene involved in RNA processing improved aging-related cell features and extended median lifespan in a small mouse ...
Heart failure does not begin when a cardiologist makes the diagnosis. By the time an ejection fraction falls below 40 percent, or an atrium lapses into persistent fibrillation, the underlying biology ...
Deep inside every skeletal muscle, scattered among the fibers that generate force, lives a population of stromal cells with a ...
肿瘤和免疫细胞抢营养,是过去十年肿瘤免疫代谢研究的核心议题。2015 年,Erika Pearce 团队在 Cell发表研究:肿瘤细胞和 T 细胞争夺葡萄糖,抢不到糖的 T 细胞 mTOR 信号和糖酵解熄火,抗肿瘤功能随之瘫痪(Cell,2015)。之后,Matthew Vander Heiden 团队进一步发现,肿瘤微环境里的营养分配并非随机:髓系细胞囤葡萄糖,肿瘤细胞垄断谷氨酰胺,各取所需(N ...