The growth and death of cancer cells in the lab are studied primarily in two-dimensional cell cultures. In a study published ...

How do different cancer subtypes arise? Do they originate from distinct cells, or from a single multipotent cell capable of differentiating into multiple cell types? This question, debated for decades ...

An international research team reports that the sphingosine-1-phosphate signaling long thought to operate inside colorectal ...

A new study by the Garvan Institute of Medical Research has uncovered a hidden mechanism explaining why breast cancer can return many years after successful treatment. Published in Nature ...

For nearly a decade, the Cancer Dependency Map, or DepMap, at the Broad Institute has helped scientists uncover new cancer dependencies - the genetic changes some cancers need to thrive that can ...

Researchers have identified a protein that helps certain pancreatic cancer cells take in a nutrient they use to grow.

ATCC and the Broad Institute report the development of engineered isogenic cancer models designed to replicate resistance to targeted therapies, beginning with osimertinib, the latest-generation ...

A Nature Aging study shows that earlier thymic involution and accelerated conversion of naive CD8+ T cells into short-lived ...

High-risk neuroblastoma is one of the most aggressive forms of solid tumors affecting children, originating in the nervous system. While a newer class of targeted immunotherapy drugs has improved ...

Chronic exposure to cigarette smoke may reprogram different populations of lung stem cells, which maintain and repair lung tissue, in ways that make them vulnerable to specific cancer-causing gene ...