The 5 performance measures meet preferred attributes such as being high value, targeting meaningful gaps in care, and being actionable, and are unlikely to have substantive unintended consequences. 3.

Background— We investigated whether increased collagen type I synthesis and deposition contribute to enhancement of myocardial fibrosis and deterioration of cardiac function in patients with ...

Stroke is a leading cause of death and disability worldwide, and the recovery process is significantly influenced by a multitude of factors beyond immediate medical treatment. Social and environmental ...

Background— The conventional protein kinase C (PKC) isoform α functions as a proximal regulator of Ca2+ handling in cardiac myocytes. Deletion of PKCα in the mouse results in augmented sarcoplasmic ...

Background— Elastin calcification is a widespread feature of vascular pathology, and circumstantial evidence exists for a correlation between elastin degradation and calcification. We hypothesized ...

In Inflammation in HIV and its Impact on Atherosclerotic Cardiovascular Disease, Obare et al 11 discuss the challenge of chronic inflammation in PLWH in the context of atherosclerotic CVD. They point ...

This Clinician Lighthouse reviews the finding of a new bundle branch block (BBB), potential underlying causes, and considerations for follow-up testing. Appropriate management requires familiarity ...

Background Artificial intelligence (AI) allows automated evaluation of intracoronary optical coherence tomography (OCT) images. However, algorithms are mostly developed and validated on well‐curated ...

Thermodynamics in the left atrium–pulmonary vein (PV) junction, phrenic nerve, and esophagus during PV isolation (PVI) using the second-generation cryoballoon are not known. Twenty dogs underwent PVI ...

Acute coronary syndrome (ACS) remains underrecognized in patients with Kawasaki disease (KD). The population at risk for KD-associated ACS is increasing, yet current ACS guidelines are largely derived ...

Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardial ischemia/reperfusion injury. Tafazzin is an ...

In multiple cell types, PI3K/AKT signaling stimulated by IGF1 regulates FOXO transcription factor function via phosphorylation and nuclear export. 25 To determine whether similar regulation of FOXO ...