A 2026 mini review concludes that microglial metabolic states may connect brain pathology with adult neurogenic niche ...

A 2026 review identifies shared pathways involving synapses, immunity, metabolism, epigenetics and waste clearance in autism ...

In the last five years, neuronal pentraxins have emerged as potential markers of synaptic loss. In the case of NPTX2, researchers may now be able to explain why. In the March 29 Science Translational ...

In the Alzheimer’s disease brain, synaptic loss correlates with cognitive decline, and is considered a sign of disease progression. But is synaptic loss always bad? Provocative new data from several ...

Researchers have shown in mice how immune cells in the brain target and remove unused connections between brain cells during normal development. This research, supported by the National Institutes of ...

Researchers from Kyushu University discovered a previously unrecognized synaptic "hotspot" that forms during adolescence, challenging the long-held view that adolescent brain development was dominated ...

A landmark study, based on genetic analysis of nearly 65,000 people, has revealed that a person's risk of schizophrenia is increased if they inherit specific variants in a gene related to "synaptic ...

Synaptic pruning is the process in which the brain removes neurons and synapses that it does not need. This usually takes place when a person is 2–10 years old. The brain contains millions of neurons ...

Researchers at Kyushu University have uncovered the mechanisms of a fundamental yet critically under-looked phase in brain development: synaptic pruning. How neurons connect and remodel themselves is ...

On a wintry Tuesday morning during the pandemic, Frederick Bennett, psychiatrist and neuroscience researcher at the University of Pennsylvania, cuddles his 8-week-old infant as he explains how brain ...