GEN

Oncogenic Signaling Shaped by a Golgi Trafficking Protein Pair

A new study in Science Signaling identifies a previously overlooked control point in receptor tyrosine kinase (RTK) signaling, one that operates not at the plasma membrane, but at the Golgi. The ...
BioWorld

Sunitinib analogue targets Shh and RTK signaling pathways, disrupts PDAC progression

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive human malignancy with a very poor 5-year survival rate of under 8%. Receptor tyrosine kinases (RTKs) are constitutively activated in PDACs. The ...
ascopubs.org

Artificial intelligence–integrated profiling of JAK-STAT, MAPK, and RTK–RAS signaling alterations in chemotherapy-treated early-onset colorectal cancer among ...

Artificial intelligence comparison of Google MedGemma and ChatGPT-5 in expert-reviewed gastrointestinal and genitourinary oncology cases. This is an ASCO Meeting Abstract from the 2026 ASCO Annual ...
Phys.org

Fluorescent tags allow live monitoring of growth factor signaling proteins inside living cells

Synthetic biologists from Rice University and Princeton University have demonstrated "live reporter" technology that can reveal the workings of networks of signaling proteins in living cells with far ...
ascopubs.org

Clinical outcomes of patients with RTK-RAS pathway alterations by treatment type: The MD Anderson Cancer Center IMPACT 2 study.

This is an ASCO Meeting Abstract from the 2026 ASCO Annual Meeting I. This abstract does not include a full text component.