The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...

Image Caption: Pyruvate inhibits TNFα/NF-κB signaling and the expression of downstream pro-inflammatory genes. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles ...

The purpose of this report is to present the findings in a group of 20 patients with pulmonary insufficiency, all but 2 of whom had arterial oxygen tensions below 50 mm. of mercury. The 20 subjects ...

Endogenous pyruvate is an end-product in glycolysis and a key molecule for ATP production under aerobic and anaerobic conditions, whereas exogenous pyruvate is transferred to cells via monocarboxylate ...

The present study was instituted to determine whether children with congenital heart disease have abnormal blood levels of lactate and pyruvate and to determine whether a relation exists between ...

Chemists have developed an organic catalyst that can drive reactions using pyruvate -- a key biomolecule in many metabolic pathways -- that are difficult and complicated to achieve using conventional ...

Please provide your email address to receive an email when new articles are posted on . The FDA approved mitapivat for the treatment of hemolytic anemia in adults with pyruvate kinase deficiency.

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...