A joint effort involving research teams from Vanderbilt University Medical Center (VUMC) and the University of Michigan has linked the activities of a regulatory gene network and functional defects in ...

Type 2 diabetes (T2DM) is a systematic multi-organ metabolic disease, which is characterized by dynamic interplay among different organs. Pancreatic islet-liver axis is closely associated with normal ...

Wenzhou Medical University researchers have reimagined the spleen as a viable site for islet transplantation, enabling long-term diabetes control without the burden of full immunosuppression.

A comprehensive study that integrates multiple analytic approaches has linked a regulatory gene network and functional defects in insulin-producing pancreatic beta cells to type 2 diabetes. The study, ...

Dynamic SMOC1 expression across differentiation supports a developmental function distinct from its association with adult T2D β-cell dysfunction and dedifferentiation signatures. SMOC1 knockout ...

Long-term Western diet impairs islet blood vessel function and insulin transport even after diet reversal and weight loss, according to a new study from researchers at Karolinska Institutet. A new ...