Spliceosomal introns are noncoding DNA sequences located between exons in many eukaryotic protein-coding genes. Most are removed post-transcriptionally by RNA splicing and do not encode proteins, but ...

Proper expression of proteins in eukaryotic cells requires precise stitching of protein-coding fragments, or exons, from precursor mRNAs that also contain non-coding introns. This process, known as ...

Spliceosome complexes remove non-coding sequences from RNA transcripts in two steps. A structure of a spliceosome after the first step reveals active-site interactions and evolutionary constraints on ...