umass

CNS Researchers Highlight Role of ‘Chaperone’ Proteins in Nervous System

A team of researchers from the College of Natural Sciences is the first to show how proteins called “chaperones” are vital in ensuring that neurons can transmit signals to one another. When this ...
EurekAlert!

UMass researchers highlight role ‘workhorse protein’ plays in keeping the nervous system running smoothly

The chaperone Hsc70 (green) helps keep SNAP-25 in the proper shape so that it can help form the SNARE complex, enabling neurotransmission. AMHERST, Mass. – A team of researchers from the University of ...
umass

UMass Researchers Highlight Role ‘Workhorse Protein’ Plays in Keeping the Nervous System Running Smoothly

A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called “chaperones” are vital in ensuring that neurons can transmit signals to one another. When ...
生物通

Hsc70–4在果蝇血细胞分化中的新型调控作用：抑制细胞应激与维持造血稳态的分子机制

本综述揭示了分子伴侣Hsc70–4在果蝇造血系统中的多重功能：通过抑制PSC（后信号中心）的非凋亡性细胞死亡和氧化应激（ROS），非自主性调控祖细胞维持；在血细胞祖细胞（特别是远端祖细胞 ...
生物通

饥饿诱导的HSC70 O-GlcNAc修饰激活分子伴侣介导的自噬

摘要： O-连接β-N-乙酰葡糖胺修饰（O-GlcNAcylation）作为一种营养调控器介导细胞信号通路。其水平因葡萄糖可利用性等多种营养因素而波动。既往研究表明，葡萄糖剥夺会上调O-GlcNAc修饰水平。