Skin fibrosis includes hypertrophic scar (HTS), keloid scar (KS), and systemic sclerosis (SSc). These conditions share ...
A new study has identified RUNX1 (RUNX family transcription factor 1) as a key driver of a harmful fibroblast state in skin fibrosis. The work shows that these cells adapt to stress, avoid a form of ...
FibroBiologics will present on fibroblast-based therapies for chronic diseases at a conference in Freiburg, Germany, on March 27, 2025. FibroBiologics, Inc., a biotechnology company focused on ...
New research led by Unity Health Toronto that examines how fibroblast cells in the body are activated to cause fibrosis and organ scarring has been published in Nature Reviews Molecular Cell Biology.
Hypertrophic scars remain one of the most persistent challenges in wound healing, often resulting in excessive fibrosis, disfigurement, and long-term functional impairment. Researchers now report a ...
This article is based on a poster originally authored by Fiona Leslie, Chloe Whiting, and Megan Webster. Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive interstitial lung disease ...
A new review identifies three fibroblast-driven mechanisms that make liver cancer cells resistant to kinase inhibitors and ...
Biomedical engineers at Duke University have developed a three-layer model of human blood vessels that enables researchers to ...
CAFs Impact ECM and tumor growth: CAFs secrete MMPs to degrade ECM, releasing growth factors for cancer cells. ECM changes counteract CAFs and tumor cells: (a) Hard ECM triggers Twist release from ...
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