New research shows that senescent cancer-associated fibroblasts in high-grade serous ovarian cancer secrete Tenascin-C, which ...

FibroBiologics will present on fibroblast-based therapies for chronic diseases at a conference in Freiburg, Germany, on March 27, 2025. FibroBiologics, Inc., a biotechnology company focused on ...

A new review identifies three fibroblast-driven mechanisms that make liver cancer cells resistant to kinase inhibitors and ...

Biomedical engineers at Duke University have developed a three-layer model of human blood vessels that enables researchers to ...

This article is based on a poster originally authored by Fiona Leslie, Chloe Whiting, and Megan Webster. Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive interstitial lung disease ...

New research led by Unity Health Toronto that examines how fibroblast cells in the body are activated to cause fibrosis and organ scarring has been published in Nature Reviews Molecular Cell Biology.

CAFs Impact ECM and tumor growth: CAFs secrete MMPs to degrade ECM, releasing growth factors for cancer cells. ECM changes counteract CAFs and tumor cells: (a) Hard ECM triggers Twist release from ...

Fibroblasts are a diverse group of stromal cells that not only provide structural support but also actively regulate extracellular matrix production and remodelling. As such, fibroblasts preserve ...

Scientists are trying to parse the cellular interactions that foment ARIA during amyloid immunotherapy. At last month’s AD/PD conference in Copenhagen, Denmark, speakers highlighted the role of both ...

Researchers identified a shared Gβγ signaling pathway driving cardiac fibroblast activation. In cell-based models and animal ...