New insights into APOBEC editing functions suggest this family of enzymes might protect against invasive attack by foreign DNA. The results uncover a notable parallel between the innate and adaptive ...
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
Despite the occurrence of multiple mutations on a single DNA strand, the mutated targets comprise only about 2% of total target DNA. The absence of mutations on 98% of the single-stranded target DNA ...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subjected to the host’s deamination system that includes the cytidine-to-uridine (C-to-U) deamination by apolipoprotein B messenger ...
The APOBEC family of enzymes plays an important role in the human immune system by driving changes in immune cells that aid in defense against viruses. A genetic mechanism is more likely to drive ...
No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2004 ASCO Annual Meeting. This abstract does not include a full text component.
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