In a recent study published in Nature Biotechnology, researchers developed a whole-genome sequencing (WGS) method that read four canonical deoxyribonucleic acid (DNA) bases, viz., adenine (A), ...

Base editors, which enable production of highly efficient targeted point mutations in genomic DNA without causing double-stranded DNA breaks, hold great promise for gene therapy in human disease and ...

The DNA base cytosine has a lot of different outfits in its closet. Most famously, the base can slip on a methyl group at its fifth carbon, a change that lends cytosine the ability to silence genes.

Chemical structure of guanine, showing its double-ring purine structure and the functional groups involved in hydrogen bonding with cytosine. (Image: Public Domain) Guanine has the chemical formula ...

DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...

Chinese scientists have found that cytosine base editors (BE3 and HF1-BE3) induce genome wide off-target mutations. Early life forms on Earth are likely to have mutated and evolved at much higher ...