A study links the high-risk CFH Y402H genotype to granzyme B activity, reduced vitronectin and membrane attack complex ...

The complement system, a proteolytic cascade within innate immunity, is tightly regulated during healthy gestation to support implantation, placental development and parturition while preventing ...

The complement system has more than 50 soluble and membrane-bound proteins. In innate and adaptive immunity, complement is essential for eliminating foreign pathogens and apoptotic cells. It is also ...

These findings suggest complement protein levels may be an important biomarker for type 1 diabetes. Disruption of the complement system appears to precede the onset of islet autoimmunity (IA), making ...

C3G and IC-MPGN can be difficult to diagnose because they are so rare and their symptoms are vague and nonspecific. A kidney biopsy is considered the gold standard and usually needed to confirm the ...