Medicines for high blood pressure are among the most widely used drugs in the world. They help protect people from heart ...

Scientists have discovered new details about how calcium controls the tightening of blood vessels, a finding that could eventually lead to more precise treatments for high blood pressure. The research ...

The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction. It mediates calcium release from the sarcoplasmic reticulum, a ...

Alzheimer's disease (AD) is the most common cause of dementia but the changes in brain cell function underlying memory loss remains poorly understood. Researchers at the University of Bristol have ...

Researchers used Cryo-EM to capture the first high-resolution 3D images of RyR1 at six stages of opening inside the intact ...

Scientists have addressed a long-standing controversy behind the molecular players mediating calcium signaling, a biological process that coordinates a wide array of physiological responses, according ...

A compound -- one of 27 million screened in a library of potential new drugs -- reversed four types of chronic pain in animal studies, according to new research. The small molecule, which binds to an ...

Calcium channel blockers are a group of medications that act to inhibit either central or peripheral calcium channels. This results in decreased calcium influx and smooth muscle relaxation.

A subunit of voltage-gated calcium channels was found to have a functional role in T-cells, according to a Northwestern Medicine study published in Nature Communications. The findings add to a growing ...

Fusion of synaptic vesicles upon calcium influx requires precise localization of voltage-gated calcium channels. A new study identifies a previously uncharacterized protein that mediates trafficking ...