Millions of people worldwide suffer from osteoporosis, a disease marked by progressive bone loss, weakened skeletal strength ...

Years to decades after breast tumors have been removed, cancer may return or metastasize in other organs. Bone is frequently affected by metastasis and in the current study published in the journal ...

Bone remodelling is a continuous adaptive process through which existing bone tissue is resorbed by osteoclasts and replaced by osteoblasts to maintain mechanical integrity and mineral homeostasis.

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the ...

Bone remodelling is sustained by the coordinated actions of osteoclasts, which resorb mineralised matrix, and osteoblasts, which deposit new bone. Osteoclasts arise from monocyte–macrophage precursors ...

An international collaboration study reveals how evolution and locomotion patterns, such as bipedalism, shaped bone structures through proteins present in the bone matrix. The findings of the study, ...

Constant remodelling of bones — up to 10% of the total mass every year — helps to maintain the optimal levels of calcium in the blood and also the structural function of the skeleton, but the identity ...

A group led by Professor Haisheng Yang (Beijing University of Technology, China) have summarized findings from in vivo mechanical loading studies to elucidate the quantitative relationships between ...

Sustained hypoxia affects orthodontic tooth movement (OTM) by altering osteoclast and osteoblast differentiation, report researchers from Institute of Science Tokyo, Japan. Hypoxic conditions resulted ...

Medically reviewed by Lindsay Cook, PharmDKey TakeawaysVitamin D3 increases calcium absorption, while vitamin K2 activates ...

Collagen is a protein found in skin, hair, nails, tendons, cartilage and bones. Our bodies naturally produce collagen using ...

Fam102a-Rbpjl axis in osteoblast differentiation reveals significant insights into bone remodeling and may aid the development of therapeutic strategies. Bones are the living tissue on which the human ...