Actin dynamics underlie the mechanical behaviour of eukaryotic cells by driving shape changes, migration and division. Monomeric actin (G-actin) polymerises into filamentous actin (F-actin) in a ...

Every time our body encounters a new disease-causing agent, a crucial defense system called adaptive immunity comes into play. T cells, the top agents in this system, survey the internal environment ...

Researchers found that attractant peptides released by female tissues initiate rapid depolymerization and repolymerization of actin at the leading edge of the pollen tube tip, steering its direction ...

Abundant, essential, and discovered more than a half-century ago, actin is one of the most studied of all the proteins. Many investigations have focused on the dynamic character of actin, leading to a ...

Actin cytoskeleton is essential for eukaryotic cells. To exert its countless cellular functions, actin undergoes dynamic remodeling orchestrated by the large number of actin-interacting factors.

Mitochondria have traditionally been viewed as energy-generating organelles, through oxidation of metabolic substrates and creation of a proton gradient across the inner mitochondrial membrane (IMM), ...

A single human cell teems with as many 100,000 different proteins. Actin is one of the most abundant and essential of them all. This protein forms into filaments that help make up the skeleton of ...

Some cells, such as immune cells, are highly mobile—they constantly remodel their shape, migrate toward a wound that needs to be closed or chase down bacteria in the bloodstream. This mobility is ...

Metastases occur when cancer cells leave a primary tumor and spread throughout the body. For this, they have to break connections with neighboring cells and migrate to other tissues. Both processes ...

Biophysicists have gained a new insight about the dynamics of cellular movement, which is key to processes ranging from stem-cell differentiation and wound healing to the development of diseases such ...