Drug developers and regulatory authorities recognize antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP) as important mechanisms of action ...
FcgRIIa-H131 and -R131 cell surface expression was measured by FACS analysis and shown to be similar (top panels). FcgRIIa-R131, but not -H131, is activated in response to Cetuximab (IgG1). Conversely ...
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